My iTunes was updated a week ago to 12.7.4 and just this morning I updated Safari and security patches for Sierra. It rebooted just fine.
It's my wife's computer, and her iMac is a 2013 model. It's possible the drive is starting to have trouble, or a file became corrupted after the update. Ever since the Time Machine restore, things are working just fine, and we've rebooted a few times. I'm not sure what the problem is, but since it's just Safari and iTunes, I've suggested she leave it be.
My Late 2012 iMac just went down two weeks ago due to a faulty logic board, and I just spend $3k on a new iMac, so I'm pretty hesitant to drag hers into the Apple Store just yet.