If the STRIX 980 Ti OC can hardly pull 275 watts, why would the manufacture put a more expensive 8 pin connectors on? Why not a 6 and a 8 pin like the newer lower power Pascal cards? I think it is for the folks that really like to overclock their equipment. So this is why ASUS put the bigger power plugs on the card.
As for how much power can be drawn from the 6 pin connector on the Mac Pro 4,1 | 5,1 , it makes sense the power protection will shut the machine down when the power supply limit is exceeded. The Mac Pro 4,1 | 5,1 has a 980 watt power supply. So if we where to use 375 watts just for the GPU, there would be 605 watts for the system. In my case I have two x5690s, If the CPUs used the max wattage there would be 345 watts left to run everything else. I think there is still enough margin on the power supply.
The pin out of the mini 6 pin PCIe AUX on the MAC PRO 4,1 | 5,1. looking at the pin diagram, you can see the only pins that provide power on both the 6 and 8 pin PCIe AUX are pins 1,2 and 3. On the 6 pin plug, pin number 2 may or may not be connected. See note in diagram.
Yes the number 2 pin is connected on the MAC PRO 4,1 and 5,1. Electrically by jumping the extra ground and sense as depicted in the picture you signal the GPU it is a 8 pin connector. If there are only two power pins in this configuration you may run into a overload issue, but the Mac Pro has all three pins powered. Yes you can draw the maximum 375 watts for a single GPU on the MAC PRO 4,1 | 5,1.
Here are the meter tests showing all three power pins connected with power.
Bit-Tech did a review on the Strix 980 Ti OC. Looks like the GPU is using well over 300 watts.
https://www.bit-tech.net/hardware/graphics/2015/08/07/asus-geforce-gtx-980-ti-strix-review/10