You should be able to do it. You need to locate the driver for the USB-CF reader and then you need to find a version of Musicmatch Jukebox for Mac. Tucows has an OS X version for download, but Musicmatch is out of the Mac business - I guess they couldn't compete with iTunes! The driver is pretty easy to find, look for USBATCF OSX. Unfortunately, there may be a bug in the driver that will cause a kernel panic when your machine awakens from sleep - do a google search on USBATCF OSX for more information. Good luck!