some people will recommend that if you are going to use an antivirus, you may want to use Norton. I have found though that Norton on Mac acts like a lot of installed PC apps, in that it will install dependencies all over the place, and trying to clean up the install (either by hand or with norton's uninstall function) is very weak at best.
I used to just use Virex to scan certain folders, and that may work well for you as well. I believe they fixed the bug of Virex running the CPU stuck at 100% buy you should check first.
at any rate virex is very lightweight, does its job well, and for what it's worth, there hasn't been a virus yet to be written for the mac. the only thing that came close was a script that would erase the users home directory, and it had to be manually clicked by the user.