I've been running Vista x64 for about a week. All the drivers work. And I have not had any real problems with any apps incl. Office 2007, Visual Studio 2008, Photoshop 7, VMWare Workstation 6, VB6 WinRar, and loads of utilites. One thing to note is that VMWare's fusion does does not support running the Vista x64 bootcamp partition. I did get it to work with some hacks, but it was a bit to slow and many of the x64 fusion drivers were missing. Hopefully this will be addressed in the next version.
Also note, if some apps crash when starting, then you may need to add them to the DEP Date Execution List, or turn DEP off. DEP is in System Properties>>Performance, (I'm in OSX at the mow, and I cannot remember the exact location
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The MacBookPro keyboard has been the worst problem for me.