1) I calibrated the battery but give it a day or two of use after calibrating for it to fully kick in.
2) I also went to Spotlight preferences and turn off all the stuff I dont want spotlight to index and search for. Basically I just turned ON apps.
3) Also installed Click2flash (for Safari) or FlashBlock for Google chrome so that I don't get floods of unnecessary flash ads that drain battery. It whitelists youtube so you should be good.
4) I also joined youtube's html5 and not flash to see if it helps the battery life.
5) I turned off auto updates for everything including apple update. I'll manually do it whenever i remember.
6) I bought Coolbook at coolbook.se (just did this today) and undervolted my CPU. It doesn't void your warranty, only works once you enter into OSX, heat goes down by 10-15 degree Celsius, AND you get better battery life.
As I'm typing this, It says 2:50 with FULL brightness and itunes open, ichat, and 6 tabs in Google chrome (1 being youtube). It's at 53%. I've never had that before today's Coolbook. In fact I never put on full brightness because it usually burns the battery around 2-3 hours after a full charge. I'm only doing it now so i can calibrate it once more but it seems to be doing real well. Totally worth the $10.
Don't have unnecessary updates or processes running in the background. The only ones i have are Bettertouchtools which allow for window snapping and resizing, spaces #, and all the stock stuff like clock, battery and wifi.