What kind of graphics are you into?
Mainly interaction design now days, and more recently user-product interaction.
What's your setup for both hardware...
I've always maintained a modest core hardware arrangement, whenever I've needed additional processing power, the most cost effective way is to just lease it and bill it.
Apple MacBook Pro
Apple Cinema Display
Apple Aluminum Keyboard (Wired)
Apple Mouse (Wired)
Western Digital Studio Edition II's
And software?
And my software requirements have slimmed even more since the last thread, too.
Adobe CS4 (Acrobat, After Effects, Flash, InDesign, Illustrator, Photoshop) handle the core creative work.
Adobe Director 11 (still the best rapid prototyping tool)
Coda & MAMP
Processing/Wiring and Arduino
Misc software such as Linotype FontExplorer X, Microsoft Office 2008 and Roxio Toast 9 Titanium also have a role in my workflow. LEGO's Digital Designer and Google Earth fill any playtime.