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I figu
I too have this problem. It is an option to select but I tap it and nothing happens. Standard and voice isolation can both be selected.
iPadOS 15.1 on an M1 iPad Pro with AirPods Pro
I figured it out. You can’t have headphones in and you have to be on a FaceTime call. It’s purpose is to gather all surrounding sound and improve it for the other person on the line. (If you’re filming at a concert and someone wants to hear the music and crowd.) The whole experience. It works
 
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