I use the ISO on PCs too, but this is not my Mac. I'm helping someone and I want to know if it's safe to update. At the moment, it has 1909 installed and updates paused.
Do you have time to fix it if something goes wrong?
Given how many of the Windows feature updates had problems in the news with past feature updates. Leading to MS withdrawing them for a few months. Only do the update if you have time to fix it. Otherwise set it to defer the update (up to one year in advanced settings) until you have time to update and possibly repair it.
Given that there are issues with devices with Intel Graphics, Thunderbolt and Thunderbolt docks. I'd definitely hold off until MS has resolved them or you have time to test and fix it yourself. At least it isn't data loss as some past updates have encountered.
I'd also set quality updates to the maximum deferred period. That way when auto updates run for them. There is a greater chance of MS catching and removing a bad update. Rather than them being one of the unfortunate guinea pigs.
At any rate. For manual updates. I wasn't referring to the full installation ISO. Just the manual download of the update for Update Assistant.