I have one... totally fantastic lens. Although handheld at 400 mm even with IS activated can still be problematic. Sometimes I'll bump up the ISO speed to get a faster shutter. But, overall I love this lens.
I've only shot with one sample, it's about what you'd expect for a prosumer zoom of this class- good quality images until you compare it with pro glass in the same focal length. It's push/pull focus, so some folks complain it drags dust into the body.