I don't use PLEX. I just serve KODI 18.3 Leia with 10TB of media drives (i.e. no transcoding), but even then I've noticed little things like in Mac Mojave, I'll get a brief 'skip' playing music from KODI over the Mac's SMB3 implementation (maybe every 10-12 songs or so and that's down from almost every song under Krypton). Since I put my 2TB SSD (was using RAID 0 which would not allow more than one boot drive) I've put Windows 10 Pro in a boot camp partition (had an 8.1 Pro license lying around I never used and you can register 10 under an 8 code for the full version) and just running the same exact media drives from Windows (I had to add MacDrive software to allow Windows to read my HFS+ media drives directly), I have yet to get a single skip playing music from the same exact player (it can't tell and couldn't care less which OS is serving the drives as they have the same network address and names regardless). So that tells me Apple's implementation of SMB3 isn't quite right (or something else interferes once in awhile with the network data). I think they should have just licensed Microsoft's version instead of writing their own.... But with the SSD, I can boot into Windows or Mac in about 20 seconds each so it's not a big deal to switch back and forth now. So IF I were going to run PLEX, I'd probaby do it from Windows 10 instead now since it has the GPU support.
I'm afraid with 10.15, the lack of 32-bit support is a game killer for the Mac anyway (I would lose quite a bit of software including Photoshop CS3, Microsoft Office 2008 and probably every Mac game ever made before a year or two ago). I may end up switching over to Windows 10 permanently once Mojave loses support for major software if that's the case. My old Photoshop 6.0 still works in Windows 10. I'm not doing that subscription thing for what I need it for so Apple's screwed the pooch on this one, IMO. They should have a sandboxed 32-bit mode or something as some software simply isn't replaceable (custom business stuff, older games, etc.) For such a rich company, I think they could have afforded to keep 32-bit support (and don't tell me it's going to make ANY functional improvement whatsoever save a few megs of disk space). Apple has made some boneheaded decisions, but this one takes the cake. Dropping all open software support (that isn't approved by Apple) will be the next big thing in a couple of years....
I'm afraid with 10.15, the lack of 32-bit support is a game killer for the Mac anyway (I would lose quite a bit of software including Photoshop CS3, Microsoft Office 2008 and probably every Mac game ever made before a year or two ago). I may end up switching over to Windows 10 permanently once Mojave loses support for major software if that's the case. My old Photoshop 6.0 still works in Windows 10. I'm not doing that subscription thing for what I need it for so Apple's screwed the pooch on this one, IMO. They should have a sandboxed 32-bit mode or something as some software simply isn't replaceable (custom business stuff, older games, etc.) For such a rich company, I think they could have afforded to keep 32-bit support (and don't tell me it's going to make ANY functional improvement whatsoever save a few megs of disk space). Apple has made some boneheaded decisions, but this one takes the cake. Dropping all open software support (that isn't approved by Apple) will be the next big thing in a couple of years....