I'm afraid Adobe is still the 'industry standard'... I see no job ads saying 'Pixelmator/iDraw skills required'...
You still have to learn the hard way.
Saying that, if I ever have to dump my adobe apps, Pixelmator is a great alternative. Still not sure about an Illustrator replacement.
Hmm ... well the end results of my works are always a PDF files (or any bitmap image format). That is, what goes into print.
So it doesn't matter what tool you use. Even if paper, pencil + scan.