Not in my experience. Since Time Machine backups started using APFS I've had not a single failure with TM to a Synology NAS backing up three Macs, one wired and two wireless. Before APFS, remote TM backups, especially over wifi, would occasionally fail and require fsck-ing which didn't always work.I do my backups with Carbon Copy Cloner. TM is even more unreliable on NAS units in my experience.