Yes, I am using a 2S with the Unifing Receiver on an M1 iMac with zero issues. Ordered a MX Master 3 regular version as an upgrade. The Unifing Receiver is better than BT.Yes I should have gotten the one with the dongle, I was lured in by the "For Mac" marketing!
NOTE: I have also set the 2S on BT and it seems to work OK but I think the UR is better.