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Anybody tried Wipr 2 yet? Gave up on Wipr 1, when it stopped blacking YouTube ads.
I have Wipr 2 and I love it. I have YT Premium, so that's not an issue for me. But it's by far the most effective and least intrusive ad blocker I can find.
 
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A new effort inspired by uBlock. Only available via TestFlight. Latest update (still a beta) was nine days ago, so as close to the bleeding edge, as we seem to get in this space. It seems pretty good so far. Also seems to be handling YT without any issues so far.

wBlock
 
Since I myself recently replaced my installation of AdGuard Home (which I think is the nicer Pi-Hole), I'd like to add a few thoughts:

One big advantage of network-wide DNS servers, besides having an anti-ad block list, is that you can get past DNS censorship and monitoring with them. However, both Pi-Hole and AdGuard Home do not contain ‘real’ DNS servers, but require that you either specify an upstream server (Quad9, dns.watch or similar), which in turn could be and often is affected by censorship or monitoring, or that you run an unbound server in parallel.

But because I'm a lazy sod, I find unbound very annoying to configure. I really like Technitium DNS, on the other hand: easy to use like AdGuard Home, open source, runs smoothly on a Raspberry Pi and taps into the root name servers by default without having to configure anything (except your ad filter lists, of course - there is a GUI for that in Technitium). Maybe this is of interest to someone here.
Couldn't one just use Little Snitch then instead of AdGuard for Mac?
 
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