Keep in mind that it will disable the ability to tab between all controls. For example, you can tab between text boxes and lists but you won't be able to tab and give focus to buttons, radio buttons, checkboxes, etc.
You can test this by going to the preferences pane where this setting lives, turning it on or off, and tabbing around. With it off, only a few controls will receive focus. Turn it on and you'll notice buttons, checkboxes, tabbed control items, etc. will all get focus as you tab through.