I use my Pro 10.5 for a lot of different things but lately I’ve been using it for note taking more and more often. I got the pencil many months ago but mainly used it for navigation. Now I’m trying to get the most out of it so I take notes for fun every chance I get... plus a little sketching here and there. I use the Notes app that came with the iPad...
For me, I like taking notes on iPad more than with paper and pen. I like everything digital though, ebooks vs real books, tablets vs. newspaper or magazine, etc...
But I recommend the iPad+pencil for note taking highly...