I've explained what to do to correct El Capitan's problems in posts 8 and 15 above.
This makes El Capitan -FASTER- on my late-2012 Mac Mini than previous versions of the OS.
And I'm booting and running from an external drive connected via USB3.
If folks don't want to give my suggestions a try, what else can I offer...?
I personally am trying other avenues which appear to me less draconian than your suggestion. I have a screen-shot of your suggestion in the folder for ideas of how to deal with this issue, and if I'm not getting better response from the system from these other approaches I'll give it a try. Sorry, but I'm just not comfortable disabling part of an OS's memory-management system. Your experience with this approach looks to be OK, but I suspect there's a certain amount of YMMV in all this in terms of both performance improvement and wheels-falling-off. Two relatively minor things I've done have provided some relief on the GUI side, a large reduction in the number of icons on the desktop (something I needed to do anyway) and shutting off Dropbox unless I need it for something.