Does the Note 2 come with a man purse?
Seriously, it's just too big for one handed operation. It also barely fits in the front pocket without having to worry about it falling out. If your a stationary person who only sits at home and sits at work, then it might be for you.
I didn't know there were so many people out there with only one hand.
I used the iPhone 4 mostly with 2 hands. I used the HTC One X mostly with 2 hands. One-handed operation is the most overblown issue in the smartphone world.