There's little-NO real world advantage to a triple channel memory configuration. OTOH, more memory is always an advantage.
At ~$50/4G I'd recommend a 4x4GB setup.
Go with 8G modules if money is not an issue.
JohnG
Agreed.....depending on what you do, MORE memory is almost always better. Last thing you want is to start swapping to disk. What good does the slightly faster triple-channel memory do then?!
Now, if you won't come close to ever utilizing anything close to 12GB....then sure, try the triple-channel config.
-Kevin