I hold the iPad in one hand (and use the other for typing) all the time. If you are suggesting you want one handed operation with a 9.7" device stick to the touch
Really?
My hand and underarm get tired holding in 1 hand. Other people noticed the same problem, so I'm not alone on this.
Perhaps the iPad 2 will be better with a reduction a weight and better weight balance in order to hold it in your hand.