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I know this is an old thread but I have the same issue, with a new 12 pro.

Have not been able to backup since restoring the last backup on it.

Given that iTunes is not being used anymore, only the finder and I see this:

Could not back up the iPhone because not enough free space is available on this Mac.
Removing files and emptying the Trash will free up additional space.
I deleted the oldest backups and cleared the trashcan and I still have ~430gb free. Cannot tell why I see this error.

I tried First Aid via Disk Utility and it did nothing.

edit: I moved the backup files to a temp folder and made a fresh backup and it worked.

Possibly an issue using an old backup file that was made with the previous phone.
 
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