Mechanical drives will die in about 1,5-2 years if you won't spin the down.
BS. we had a storage array at work that was powered up 24/7 that had only 2 drive failures (out of 24 drives) in 5+ years.
What killed it? AC Failure. The server room got up to 55 degrees celsius, and the following week one drive failed. Another one failed a few months later. Allegedly, the grease in the bearings gets too hot, then the bearings dry out. No idea if that is true, but I've definitely seen things (drives, CPUs, RAM) fail shortly after over temp.
I have other PC servers that have been powered up continuously, barring extended power outage for 7+ years.
Power surge from power on is what will kill things, along with excessive heat.