Yup. in my MacPro I had a 2nd drive dedicated to audio samples, but I'm consolidating everything in the iMac. I think it should be fine, I almost partitioned the drive into 2 1TB volumes (one for system, one for audio) but I figured I'd try this and if it's not optimal I'll move the samples back to a dedicated FW800 drive.
Why would you split the drivers in two? something related to the audio? I read somehting about that last month and I didnt get it. I use Pro Tools 8 LE for music production and I was wondering about two things. Is the i5 good enough for music apps to run without with any problems (this means I dont have to spend more for the i7) and why people are using 2 HD for audio purposes.