Yesterday I worked with a really big PSD file, alongside some smaller ones, and Photoshop was taking 12Gb RAM. I also had around 5.6Gb RAM in Safari, with some web-apps. I also had a few Gb taken by other apps - if I just added them up (which you shouldn't do as it tells you very little) it would amount to over 20Gb RAM in total.
Now, whether it was compressed RAM or some other dark magic, my swap file was only 30Mb. In fact, even as I opened more documents in Photoshop, it stayed that way. What is more important is that computer was
super responsive and I had literally no change in performance. These beasts just don't stop. (Note: I rarely see my Mac swap, but even when it does, the performance remains unchanged).
So, I'm not saying 16Gb is enough for everyone, I'm saying that
you can't measure your requirements precisely by looking at the amount of memory your apps take. It is more complex than that and depends on what you're working on.
I've had this computer for several months now, it didn't slow down once. I have never seen it struggle, no matter what I was doing. I work with large Photoshop files, with Zbrush, with demanding web-apps, etc. It's not one of the most demanding workflows (I'm not working with huge audio files, multiple 100Mp photos at once or 8K video files), but it's not "browsing & email" work either.
So, the answer to any RAM related question, like, is 16Gb enough, is 32Gb enough, is 64Gb enough - is always: it depends. I've seen so many posts that say "well, Safari is taking 10Gb of my RAM, meaning that I have only 6Gb remaining for other apps, that means I need 32" - it doesn't work that way.