Best practice with Diablo IV and Crossover is to set up your bottle with D3DMetal + Esync. It may work on DXVK but the best performance is with the settings I just mentioned. I can tell you that with Diablo IV, it won't run with
just D3DMetal, or
just Esync, it needs both of them enabled (see below). MSync does not apply for Diablo IV, do not use it with that game.
Use Crossover to make you a Diablo IV bottle using the built-in recipes if you don't feel like messing with the bottle's individual settings.
I've done some not-insignificant testing with Crossover and my Steam library at this point. If you have any more questions, not just about Diablo IV, feel free to ask!
Also! I highly recommend enabling high-performance fan mode in system settings if you haven't done so already!
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