Nobody outside Apple has any good data on Fusion Drive reliability. The SSD portion and HDD are like RAID-0, so they both must work. However any HDD, SSD or hybrid drive can fail at any time, and even pure SSDs can have significant failure probabilities.
It might at first seem that 2TB Fusion Drive is more likely to fail than a similar-size SSD, but the SSD in that case is 16x larger than the 128GB SSD in FD. It has a lot more storage cells to fail or get hit by a cosmic ray, so it may have different failure characteristics. I personally think the SSD is more reliable but you can't go by "gut feel".
We do know that SSD itself can have significant failure rates. Worse, unlike an HDD which often gives off warning signs of an impending hard failure, SSD often just totally dies. SSD reliability studies and discussions:
http://www.enterprisestorageforum.c...sd-vs.-hdd-performance-and-reliability-1.html
http://www.rockpapershotgun.com/2014/01/30/are-ssds-reliable/
http://www.tomshardware.com/reviews/ssd-reliability-failure-rate,2923.html
I don't see that Fusion Drive makes any difference in terms of backup plan -- they must all be backed up or you risk losing your data.