Kernel panic reports can certainly help determine the issue, so guesswork is out of the equation.
Thank you for quick response.
Here is a log
*** Panic Report ***
panic(cpu 6 caller 0xffffff8015fdd5bd): "TLB invalidation IPI timeout: " "CPU(s) failed to respond to interrupts, unresponsive CPU bitmap: 0x1, NMIPI acks: orig: 0x0, now: 0x0"@/Library/Caches/com.apple.xbs/Sources/xnu/xnu-3789.70.16/osfmk/x86_64/pmap.c:2724
Backtrace (CPU 6), Frame : Return Address
0xffffff8745963940 : 0xffffff8015ee953c
0xffffff87459639c0 : 0xffffff8015fdd5bd
0xffffff8745963a60 : 0xffffff8015fe48c2
0xffffff8745963b80 : 0xffffff8015fe58fa
0xffffff8745963bf0 : 0xffffff8015f721a8
0xffffff8745963d30 : 0xffffff8015f71aac
0xffffff8745963d60 : 0xffffff8015f6d4a3
0xffffff8745963d90 : 0xffffff8015ef4cdd
0xffffff8745963db0 : 0xffffff8015ecb6dc
0xffffff8745963e00 : 0xffffff8015edf34c
0xffffff8745963e80 : 0xffffff8015edf902
0xffffff8745963f10 : 0xffffff8015fea198
0xffffff8745963fb0 : 0xffffff8015e9adb6
BSD process name corresponding to current thread: UserEventAgent
Mac OS version:
16G29
Kernel version:
Darwin Kernel Version 16.7.0: Thu Jun 15 17:36:27 PDT 2017; root:xnu-3789.70.16~2/RELEASE_X86_64
Kernel UUID: D3314D98-5D40-3CD8-98A4-F1DD46C20E03
Kernel slide: 0x0000000015c00000
Kernel text base: 0xffffff8015e00000
__HIB text base: 0xffffff8015d00000
System model name: MacPro5,1 (Mac-F221BEC8)
System uptime in nanoseconds:
520148467147
last loaded kext at
512024841492: com.apple.driver.AppleHIDKeyboard 199 (addr 0xffffff7f98bce000, size 32768)
last unloaded kext at
370134273485: com.apple.filesystems.msdosfs 1.10 (addr 0xffffff7f98bc7000, size 61440)
loaded kexts:
com.apple.driver.AppleHWSensor 1.9.5d0
com.apple.driver.AudioAUUC 1.70
com.apple.driver.AppleTyMCEDriver 1.0.2d2
com.apple.driver.AGPM 110.23.17
com.apple.filesystems.autofs 3.0
com.apple.driver.AppleMikeyHIDDriver 131
com.apple.driver.pmtelemetry 1
com.apple.iokit.IOUserEthernet 1.0.1
com.apple.driver.AppleUpstreamUserClient 3.6.4
com.apple.driver.AppleMCCSControl 1.3.4
com.apple.driver.AppleHDA 279.48
com.apple.driver.AppleMikeyDriver 279.48
com.apple.GeForce 10.1.7
com.apple.iokit.IOBluetoothSerialManager 5.0.5f1
com.apple.Dont_Steal_Mac_OS_X 7.0.0
com.apple.driver.AppleOSXWatchdog 1
com.apple.driver.AppleHV 1
com.apple.driver.AppleLPC 3.1
com.apple.driver.AppleIntelSlowAdaptiveClocking 4.0.0
com.apple.driver.ACPI_SMC_PlatformPlugin 1.0.0
com.apple.driver.AppleUSBDisplays 380
com.apple.iokit.IOAHCIBlockStorage 295.20.1
com.apple.iokit.SCSITaskUserClient 394.50.1
com.apple.driver.AppleFWOHCI 5.5.5
com.apple.AppleFSCompression.AppleFSCompressionTypeDataless 1.0.0d1
com.apple.AppleFSCompression.AppleFSCompressionTypeZlib 1.0.0
com.apple.BootCache 40
com.apple.driver.AirPort.Brcm4331 800.20.26
com.apple.filesystems.hfs.kext 366.70.1
com.apple.driver.Intel82574LEthernet 2.7.2
com.apple.driver.AppleAHCIPort 326.60.1
com.apple.driver.AppleRTC 2.0
com.apple.driver.AppleHPET 1.8
com.apple.driver.AppleACPIButtons 5.0
com.apple.driver.AppleSMBIOS 2.1
com.apple.driver.AppleACPIEC 5.0
com.apple.driver.AppleAPIC 1.7
com.apple.driver.AppleIntelCPUPowerManagementClient 219.0.0
com.apple.nke.applicationfirewall 172
com.apple.security.quarantine 3
com.apple.security.TMSafetyNet 8
com.apple.driver.AppleIntelCPUPowerManagement 219.0.0
com.apple.driver.AppleHIDKeyboard 199
com.apple.driver.usb.cdc 5.0.0
com.apple.kext.triggers 1.0
com.apple.driver.DspFuncLib 279.48
com.apple.kext.OSvKernDSPLib 525
com.apple.iokit.IOSurface 159.9
com.apple.iokit.IOAcceleratorFamily2 311.14
com.apple.nvidia.driver.NVDAGK100Hal 10.1.7
com.apple.nvidia.driver.NVDAResman 10.1.7
com.apple.AppleGraphicsDeviceControl 3.14.49
com.apple.iokit.IOSerialFamily 11
com.apple.driver.AppleSMBusController 1.0.18d1
com.apple.iokit.IONDRVSupport 516.1
com.apple.iokit.IOFireWireIP 2.2.7
com.apple.driver.AppleSSE 1.0
com.apple.driver.AppleHDAController 279.48
com.apple.iokit.IOGraphicsFamily 515.3
com.apple.iokit.IOHDAFamily 279.48
com.apple.driver.AppleSMBusPCI 1.0.14d1
com.apple.iokit.IOSlowAdaptiveClockingFamily 1.0.0
com.apple.driver.AppleSMC 3.1.9
com.apple.driver.IOPlatformPluginLegacy 1.0.0
com.apple.driver.IOPlatformPluginFamily 6.0.0d8
com.apple.driver.AppleUSBAudio 308.7
com.apple.iokit.IOAudioFamily 205.15
com.apple.vecLib.kext 1.2.0
com.apple.driver.usb.IOUSBHostHIDDevice 1.1
com.apple.iokit.BroadcomBluetoothHostControllerUSBTransport 5.0.5f1
com.apple.iokit.IOBluetoothHostControllerUSBTransport 5.0.5f1
com.apple.iokit.IOBluetoothHostControllerTransport 5.0.5f1
com.apple.iokit.IOBluetoothFamily 5.0.5f1
com.apple.driver.usb.networking 5.0.0
com.apple.driver.usb.AppleUSBHostCompositeDevice 1.1
com.apple.driver.usb.AppleUSBHub 1.1
com.apple.iokit.IOSCSIMultimediaCommandsDevice 394.50.1
com.apple.iokit.IOBDStorageFamily 1.8
com.apple.iokit.IODVDStorageFamily 1.8
com.apple.iokit.IOCDStorageFamily 1.8
com.apple.iokit.IOAHCISerialATAPI 266.50.1
com.apple.iokit.IOSCSIArchitectureModelFamily 394.50.1
com.apple.iokit.IOFireWireFamily 4.6.6
com.apple.iokit.IO80211Family 1200.12.2
com.apple.driver.corecapture 1.0.4
com.apple.filesystems.hfs.encodings.kext 1
com.apple.iokit.IONetworkingFamily 3.2
com.apple.iokit.IOAHCIFamily 288
com.apple.driver.usb.AppleUSBEHCIPCI 1.1
com.apple.driver.usb.AppleUSBUHCIPCI 1.1
com.apple.driver.usb.AppleUSBUHCI 1.1
com.apple.driver.usb.AppleUSBEHCI 1.1
com.apple.driver.usb.AppleUSBHostPacketFilter 1.0
com.apple.iokit.IOUSBFamily 900.4.1
com.apple.driver.AppleUSBHostMergeProperties 1.1
com.apple.driver.AppleEFINVRAM 2.1
com.apple.driver.AppleEFIRuntime 2.1
com.apple.iokit.IOHIDFamily 2.0.0
com.apple.iokit.IOSMBusFamily 1.1
com.apple.security.sandbox 300.0
com.apple.kext.AppleMatch 1.0.0d1
com.apple.driver.AppleKeyStore 2
com.apple.driver.AppleMobileFileIntegrity 1.0.5
com.apple.driver.AppleCredentialManager 1.0
com.apple.driver.KernelRelayHost 1
com.apple.iokit.IOUSBHostFamily 1.1
com.apple.driver.AppleBusPowerController 1.0
com.apple.driver.DiskImages 444.50.16
com.apple.iokit.IOStorageFamily 2.1
com.apple.iokit.IOReportFamily 31
com.apple.driver.AppleFDEKeyStore 28.30
com.apple.driver.AppleACPIPlatform 5.0
com.apple.iokit.IOPCIFamily 2.9
com.apple.iokit.IOACPIFamily 1.4
com.apple.kec.Libm 1
com.apple.kec.pthread 1
com.apple.kec.corecrypto 1.0
Model: MacPro5,1, BootROM MP51.0089.B00, 12 processors, 6-Core Intel Xeon, 3,06 GHz, 64 GB, SMC 1.39f11
Graphics: NVIDIA Quadro K5000, NVIDIA Quadro K5000, PCIe, 3584 MB
Memory Module: DIMM 1, 16 GB, DDR3 ECC, 1333 MHz, 0x80CE, 0x4D33393342324737304248302D5948392020
Memory Module: DIMM 2, 16 GB, DDR3 ECC, 1333 MHz, 0x80CE, 0x4D33393342324737304248302D5948392020
Memory Module: DIMM 5, 16 GB, DDR3 ECC, 1333 MHz, 0x80CE, 0x4D33393342324737304248302D5948392020
Memory Module: DIMM 6, 16 GB, DDR3 ECC, 1333 MHz, 0x80CE, 0x4D33393342324737304248302D5948392020
AirPort: spairport_wireless_card_type_airport_extreme (0x14E4, 0x8E), Broadcom BCM43xx 1.0 (5.106.98.100.26)
Bluetooth: Version 5.0.5f1, 3 services, 27 devices, 1 incoming serial ports
Network Service: Wi-Fi, AirPort, en2
PCI Card: NVIDIA Quadro K5000, Display Controller, Slot-2
PCI Card: NVIDIA Quadro K5000, NVDA,Parent, Slot-2
Serial ATA Device: HL-DT-ST DVD-RW GH61N
Serial ATA Device: Samsung SSD 850 PRO 512GB, 512,11 GB
Serial ATA Device: SAMSUNG SSD 830 Series, 256,06 GB
Serial ATA Device: WDC WD10EZRX-22A3KB0, 1 TB
USB Device: USB Bus
USB Device: USB Bus
USB Device: USB Bus
USB Device: BRCM2046 Hub
USB Device: Bluetooth USB Host Controller
USB Device: USB Bus
USB Device: Intuos5 touch L
USB Device: USB Bus
USB Device: USB Bus
USB Device: USB 2.0 Bus
USB Device: USB 2.0 FD
USB Device: Hub
USB Device: Apple LED Cinema Display
USB Device: Display iSight
USB Device: Display Audio
USB Device: USB 2.0 Bus
USB Device: USB 2.0 Hub
USB Device: SteelSeries Rival 110 Gaming Mouse
USB Device: Keyboard Hub
USB Device: Apple Keyboard
FireWire Device: built-in_hub, Up to 800 Mb/sec
Thunderbolt Bus: