Update: I just wanted to post and let others know what setup I went with. I bought a Drobo, added (2) 2TB Hitachi Deskstar 2TB 7200rpm - 7K2000 drives. LOUD, which vibrated the drobo to make this aweful growling sound not to mention the noise of data access. I called Dell and they have started a return. I ran to Best Buy the next day and bought (2) 2TB WD Caviar Green drives. What a difference. The Drobo is now really quiet. The only time I hear it is when I am close to my entertainment center and the fan is running when accessing heavy data.
With the two drives the Drobo gives me about about 1.75 TB of free space. I will add 2 more when I get low. I love the option of using any combination of drives. Drobo Dashboard is easy to use and it formatted the drives pretty quickly. Throughput is slower than most external 4-bay enclosures but not too slow for streaming movies and music. I have had no performance/streaming issues from the Drobo with mkv, iso, img, avi, m4v with Plex.
I now have to think of a backup solution. Even though the Drobo allows you to hot swap the drive if one fails, with any RAID system you must have a backup of the data in a separate location. So, maybe a 4 bay QNAP or another Drobo. We'll see.
I am running the Mac Mini with Plex. The interface is pretty sweet. Using this setup over the Apple TV is a lot more flexible, although pricey.
I just bought a new Drobo FW800 and also using the Hitachi 7K2000 2TB drives. Other than the drives running much hotter than the 1TB 7K1000.B that I have my Drobo is silent. I don't have any of the vibration problems.
I agree that the Drobo over FW800 is way slower than any other FW800 enclosure I've ever used. Maybe it's the RAID that's slowing it down.