I have similar issue on MBP 15 inch, 2017. In my case 10.14.4 becomes unresponsive = slow to activate other app windows after sleeping while attached to external monitors (one 4K and one 2k) and docking station with TM disk. Once app is activated (slow), its windows behave marginally OK, still slow, but usable. But keyboard response (typing) is slow also, so not useful. Interestingly, mouse movements are as fast as ever.
Reboot fixes it. Sleep with no external devices (monitor, dock, disks) attached and lid closed is fine, overnight or simply between work and home. But 60+ minutes sleep on desk with Lid opened and all cables/devices attached, and it becomes impossible to switch between apps. Disconnecting the 4K monitor hangs computer completely, resulting in hard reboot. No solution yet. Reported to Apple as bug, it was not in 10.14.3.
If anyone has similar issue and some insight, please, share.