A few months ago I wanted to prep my 1,1 for FCPX Motion, et. al. and knew I needed to get an OpenCL card like the ATI 5770.
So I did the research, and took the risk. Oh, and I decided to go all the way to a 5870, in for a penny...
So I made sure I was up to spec on Lion, and popped it in. Seamless. Yes, I know it really wants PCIe 2, so the card is fairly bored, but I'd rather the card not be the bottleneck. And it sure isn't... it eats children...
So if you are curious, yes, as long as you have Snow Leopard or above (EFI firmware provided by that is needed for these cards), the ATI 5770 and 5870 will drop right in.