Maybe this will help. Illustrator:
http://help.adobe.com/en_US/illustrator/cs/using/WSfd1234e1c4b69f30d2a5051004d659b1c-7ff6a.html
I can't see how it would help unless I had a profile for their printer(s), where "their" = Lightning Source's, in Tennessee, and they don't offer one. LS is a very large high-speed print-on-demand operation and I have no idea what sort of printers they use.
They seem to think it's unimportant, because nowhere in their instructions for their clients do they talk about profiles or setting up for anything at all except the proper Adobe specs and CMYK, as in the section I quoted. I've delivered 7 cover PDFs to them and they've said nothing (and except for the one with the blacks problem, they all turned out well).
Am I missing something here?