I think you guys blow it out of proportion, but hey I'm not making your decisions for you. If it really bothers you that much, then fine don't buy the phone. I personally think the decision to make the sleep/wake button the IR blaster was a nice touch and don't mind (dare I say prefer) the button on top.
I know I'm in the minority (at least here). I'm shuffling my hand regardless using any phone taller than the iPhone 4S (even the 5) so I don't see how its that much more inconvenient.
Anyways - I accidentally pressed the lock button more than once on my N4 so to HTC I say bravo!