Thanks so much Selsk... you nailed it... I had 2 consistent problems... I have a MacBook Pro running Catalina with two 24" monitors extending the desktop... one was horizontal and one was vertical. Every time I woke up (or rebooted) the system, the content on the vertical monitor would default to horizontal again (would have to continually change rotation in System Preferences > Display > Rotation)... the second problem was that my desktop wallpaper would also reset to the Catalina default.... Then I had another issue where my desktop wallpaper would reset to the Catalina default after every reboot. Did a lot of research and turned off 'Displays have separate Spaces" in Mission Control Preferences. That fixed that.
After reading your post, went to System Preferences > Mission Control and unchecked "Displays Have Separate Spaces" and both problems have now been fixed... vertical content stays vertical and wallpaper has returned.
Thanks so much for your research and sharing.