I like symmetry
I keep:
3 three communications apps on the bottom, centered
8 utility apps on the left.
12 main apps in the middle, organized vertically into workday apps, then media apps, then internet apps, & horizontally by relevance.
8 stupid items like a few games and webclips on the right.
I keep it on the main screen of twelve, since I use them the most, and it keeps the center dot (of three) bold.
If I add an app, I have to take something else off.
I use a black theme at work, and a white colorful theme when not.
I am not ocd. I am not ocd. I am not ocd...
When my employees got a little too grabby, I took the screenshot of my springboard with all the apps on it, set it as my wallpaper, and then slid all my apps off to the sides, so when they'd pick up my phone and try tapping on things, nothing would happen.