Sure thing. I travel with it quite a bit (although I am thankfully flying less and less). It easily fits clothes for a day. I usually wear the same suit/shoes and switch everything else for the second day. A second suit would take up a lot of room in it, and a second pair of any shoes but small loafers destroys the room in the case.
The case is actually pretty small. It is carryon compliant on every carrier, but some of the smaller prop planes that ban anything with wheels in the cabin get fussy. It will fit in all of the bins at gates, which means that the interior of the case is significantly smaller than the footprint because of the ribbing and liner. I inner dimensions of the main compartment with the liner in are 10.5"w 19.5"l and 5"h.
The laptop case is for THICK computers, but not as much big ones. A 13" or 15" MBP might inspire one of the "hotdog down a hallway" comments, but I think a 17" would be a serious stretch. I generally throw my 13" in there in its case, and include the power brick, airplane adapter, and iphone cables.
I use the little bag for toiletries, figuring any spill would be contained by the clear bag and that one.
All three of the compartments can come out, and you can add the foam if you want. Because this case is new, and most likely to be used by corporate people, there is a big premium to get the liners, which was a little frustrating, but I have been very happy with the pelican cases, so I paid up.
Here are my complaints, some of which will be true for most carryons:
-A pair of gym shoes just becomes an impossibility.
-It is quite heavy.
-Some TSA people will mistake you for transit police.
-It looks just like the pelican cases that people use to transport all manner of expensive and breakable things.
-It can be a pain to close if overfilled.
-The big liner could have been top only, giving a little more room. It is not like my shirts and ties are offended by touching hard plastic.
-I wish the lock locations were a little more balanced so it would be an option to attach a shoulder strap.
The good to make up for it:
-It looks nice enough, much more understated than most hard-shell luggage.
-It can put up with everything the other pelicans can.
-If you ever had a Hudson landing, you could float on it.
-Many employees recognize the case, so there is not a lot of "will it fit" questioning.
-There are no straps, etc to get caught on anything.
-There are two handles, and it is actually not all that awkward to carry.
-It is quiet and well balanced. No squeaking wheels or bearings.
I forgot to mention, I would buy it again in a second.