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I usually wait until at least .3, but on this occasion I did my research and upgraded my Mac Pro. No regrets, no huge bugs, many things feel faster and I love the new Mail app.

I make a living on this Mac so I still have a SL clone if I need it, but it's been two weeks now and no problems per se. I run CS5 Design Premium, Font Explorer, Transmit, Pages, Cronosync, CrashPlan plus other odds and sods. Nothing in full screen mode.
 
Well. I did it. I upgraded. I spent a few days in it. Learned all the new commands to actually customize it. Then I quickly reinstalled 10.6.8. Lion has been relegated to externals for testing only right now. Not sure if it is a total turd (not talking bugs, talking design and implementation) or not. Eventually I will have to take the plunge with new HW but yeah...
 
I've already upgraded my personal machines, but we use two different Mac Pros in our recording studios. We use Pro Tools and have been informed by Avid that it is not yet compatible with Lion.

After using it since its release on my personal machines I have no concerns about switching for professional use--we just have to wait on Avid. Judging on past experience, that may be a long wait.

Check with the developers of the pro software you use. If they say it's compatible, you should be good to go. If not, wait. Some developers are better than others.
 
I'm waiting. Maya doesn't not have an update for Lion yet so its a no go for me. Same goes for Wacom not having new drivers yet, that is also another no-go.

I haven't even bothered to check the rest of my apps yet since I can't upgrade without Maya's compatibility.

I need:

Photoshop CS5
ZBrush 4
Corel Painter 11 (12 soon)
Unity 3D

and a slew of others but once I know for sure the above work I can upgrade.

I'd like to upgrade since Lion supports OpenGL 3.2 and I am currently learning (attempting I should say) the new pipeline.
 
Like many others I've upgraded my MBP that mainly use for travel/couch surfing and everything seems fine but I'm waiting until Wacom and Adobe are 100% up to speed on Lion compatibility.
 
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