One thing I DO notice is that the three monitors blink 2-3 times (going black for a split second) after logging in (which did not happen on the 5,1) - for this reason, I still think this problem may come back to the W5700X card implementation?
I also have a W5700X and see the same thing, albeit not every time (in fact not so much now). But with my older monitor it was even worse, there wasn't only this blinking, but also instances where I would see some kind of "snow" (similar to the artefact which old TV sets show when there is no signal), and sometimes that "snow" would even stick and not go away after a second. Shutting down the monitor (using the "real" power switch, not the "soft" power switch) and switching on again helped, but problem surfaced again from time to time. The newer monitor (also an EIZO, but thsis time in 4k) did not show the snow, but some blinking, but only one time right after I installed it.
As I see it - especially as you have a similar experience - I do not think the W5700 has a hardware issue (at least not one that wasn't just designed to be that way ...), but there seems to be a kind of negotiation problem between GPU and Monitor, so maybe EDID related? Not sure where it comes from but I would say its software / driver related, as I do not see the same behavior in Bootcamp. So you might also check another monitor to see if it behaves the same.
What I also had was one or two "hard locks" where the screen just
completely froze, so I was forced to shutdown the machine by long pressing the power button. This was just at the beginning of my setup and hasn't appeared since, so I _hope_ it was just some setup glitch.
Other than that I, also use Adobe and hadn't any crashes or even shutdowns with it, but admittedly I am trying to avoid using that Adobe sh*tware as much as I can, so I haven't really thoroughly tested it. However, I also tested some older AE projects and they rendered just fine.
Finally, did you do a _thorough_ RAM test, including switching / taking out sticks? Those seemingly random crashes in different apps and with different symptoms are quite typical with faulty RAM, and that can be hard to detect. Start with rember, but be aware that rember cannot test all of your ram. For best results, memtest86 on a bootable DOS drive.
PS: also like you I had a freeze when waking from sleep, but fortunately only once, shortly after I made the mistake to test Big Sur (which in turn updated the firmware, so beware!). Not sure if this was the reason (KP logs also pointed out to an EFI issue), but wasn't able to reproduce since then.
All in all I am in a similar situation like you, as I also do not know if I should love or hate the machine. I mean the design and hardware is gorgeous, the cooling system top notch, but also the single core performance improvements where a bit "meh" compared to my 7 year old hackintosh. But worst of all many many little glitches (or sometimes worse) so I always have the feeling that my system is not 100% stable.
But my gut feeling tells me that most if not all of it is software related. As I do graphic design AND development, my setup is quite complex and also many things are modified and tweaked, including using things like Lilu/Innie.
Ah, and I remember also getting freezes while gaming in Bootcamp two or three times so I also think especially the W5700X isn't really well optimized driver wise (and that seems to be true for both win and mac), and that's also what I have heard from other sources on the internet. I think I would have been better of with the Vega II, if it only wasn't for that insane price ...
And you will hear the fans in all their full glory 