The problem is really low level, USB1.0 and USB1.1 OHCI devices, what is called legacy USB, are 32bit only and require to have a very computationally expensive bounce buffer for 64bit usage - Apple started the OHCI chopping block back with Big Sur since no supported Macs are OHCI anymore and this will only get worse over time, it's EHCI/xHCI or bust now.
Since Mac Pro Intel USB controllers are OHCI for the USB1.0/1.1 speeds, this is a real issue for us, but not for modern hardware where the USB controllers are EHCI/xHCI native.
So, would a USB3 (or 2) PCI card also be a solution (assuming it would have a more modern controller on the card)?