I'm a data hoarder and I currently own all the hard drives mentioned except for G-Drive and Samsung T5. I use Carbon Copy Cloner for everything. I have an 256GB MBA with SSD which I used to backup on a 256GB SATA SSD with enclosure. I also had 4 x 2TB 2.5 portable USB hard drives (2 x 2TB backed up to the other 2 x 2TB) and 2 x 1TB (1TB backed up to the other 1TB) which were Western Digital, Seagate (Expansion and Backup Plus) and Maxtor. I've had them for about 5 years or more. All of them are still working fine — but they are being "retired" (to be used for non-important files that we won't mind losing if the drives decide go to hard disk heaven
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In addition, my partner had 2 x 6TB 3.5 WD Red NAS HDs for a total of 12TB which were backed up to another 2 x 6TB WD Red NAS using CCC. He set it up as a raid 0. We bought them all at around the same time as the 2.5 drives. Recently all these 3.5 drives were failing so my partner decided to get a 2 x 6TB WD My Book to replace the failing drives, but he did not like all the power cables that powered the WD My Book.
So, last Black Friday, we decided to go on a shopping spree and bought 4 x 5TB WD Elements to consolidate the files in all of our 1 and 2TB drives, as well as 1TB Sandisk Extreme SSDs to backup our computers. So far, the experience has been great. We are using Carbon Copy Cloner to move and backup the files, and set it up on a daily schedule.
We never used the built-in encryption software that comes with all these drives. Every time we buy a new drive, we reformat everything (erase and partition/add volume) using Disk Utility, encrypt the drives using FileVault, then we use CCC to transfer and set up the backup schedule.
Next Black Friday, I'm most likely getting a Samsung T5 SSD to try it out because I heard good reviews about it (and it's supposed to be cooler temperature-wise than Sandisk Extreme). I'm currently using Sandisk Extreme for my daily backup, but I hope to use the Samsung T5 as a backup or a startup drive for one of my old iMacs.
For all these drives, we use a 10-port and a 7-port powered USB hubs from ORICO. We love them except for the fact that each hub comes with 2 USB charging ports, and the charging ports eventually become unreliable. Every time this happens, we buy a new hub. I'm open to recommendations from anyone who actually have hubs with reliable charging ports.
TLDR — I've tried almost all the drives mentioned in the thread. Never had any problems with CCC. I never used the encryption software that comes with the drives. I used Disk Utility to reformat and encrypt everything. All drives are still alive and well, except for the 3.5 WD Reds.