From Wikipedia:
and:Modules rated at different speeds can be run in dual-channel mode, although the motherboard will then run all memory modules at the speed of the slowest module. Some motherboards, however, have compatibility issues with certain brands or models of memory when attempting to use them in dual-channel mode. For this reason, it is generally advised to use identical pairs of memory modules, which is why most memory manufacturers now sell "kits" of matched-pair DIMMs. Several motherboard manufacturers only support configurations where a "matched pair" of modules are used.
A matching pair needs to match in:
-Capacity (e.g. 1024 MB). Certain Intel chipsets support different capacity chips in what they call Flex Mode: the capacity that can be matched is run in dual-channel, while the remainder runs in single-channel.
-Speed (e.g. PC5300). If speed is not the same, the lower speed of the two modules will be used. Likewise, the higher latency of the two modules will be used.
-Number of chips and sides (e.g. 2 sides with 4 chips on each side).
-Matching size of rows and columns.
Somebody knows what they mean by "best dual-channel operation"? Is there anything other than the possible compatibility issues if you have different capacities?These separate channels allow each memory module access to the memory controller, increasing throughput bandwidth. It is not required that identical modules be used, but this is often recommended for best dual-channel operation.