Even though the website states differently this USB 3.0 card works out of the box with my cMP 2,1 (OS X 10.11)
4-Port USB 3.0 PCIe Express Card for Mac Pro KT4004
Expansion of 4 ports USB 3. 0 connections; No additional power supply for normal recognition and operation needed anymore, fast and easy installation, keeps your Mac Pro case tidy Compatible with Windows XP/ Vista/ 7/ 8/ 10. Windows 10 and Mac 10.8.2 and more latest systems are built with a...www.inateck.com
You need proper USB cables for it and sometimes power-hungry drives can cause problems.
It is always a good idea to power external mechanical drives with the AC > DC auxiliary power port on the dock or enclosure . With a SSD , you shouldn't have to worry about it .