Same question, same rhetoric;
As someone who relies on their Mac`s for a living absolutely yes...
There are several reasons to run antivirus/malware detection on OS X especially if you are dealing with a mixed environment passing on malicious code, even inadvertently will do you no favours in the professional world, let alone family and friends. What does not hurt OS X may bring a Windows to it`s knees. By far the vast majority of companies that you may potentially work with, or interact with will require a level of antivirus protection, regardless of platform.
You do need to be careful on the choice of application; perviously I ran ClamXav as the app is extremely light and only looks in realtime at what you specify, it`s free, equally time has moved on and ClamXav has remained rather static. I now use Avast. Same scenario no impact to performance with a greater scope of realtime protection. Does anyone seriously still believe that running Avast or ClamXav on todays modern hardware impacts performance! The paid for packages I agree are unnecessary on OS X, as the free alternatives are more than good enough presently.
Avast or ClamXav will have no impact on a modern Intel based Mac. To have a free, low headroom, accurate scanner and not utilise it, is somewhat stubborn at best. The retorts of AV being a resource hog, boils down to one thing, research; Avast or ClamXav will not bog your system down. If it does your system has other inconsistencies that need addressing, or your hardware is so old it`s well and truly time to upgrade. On my Early 2008 2.4 MBP ClamXav is simply invisible, there is absolutely no degradation of performance, as for the Late 2011 i7 2.4 MBP, Mid 2012 Retina & new 2.8 13" Retina it`s completely transparent, as is Avast, same applies to the rest of the Mac`s in the household.
I have literally decades of work on my systems, and have no intention of losing any data, or suffer downtime. Antivirus is but one tool in a multilayered safety net. Lets face it, if and when OS X is compromised it will spread like wildfire as many fundamentally believe that OS X is invulnerable, then it will all be done, bar the shouting. I am not entirely sure posts that overly reinforce this false sense of security are helpful to the average user, even Apple recognise the threat, however the updates are too slow to be considered a truly preventative measure. As of OS X 10.6 your Mac is running anti malware like it or not courtesy of Apple. Virus/Malware gains traction by exploiting vulnerabilities on unprotected systems. I don't believe for one second that any antivirus/malware detection application is the single security solution for OS X, it is however one of several effective barriers.
I have never had a positive hit in all the years I have run ClamXav and now Avast equally OS X is gaining ever more traction and it`s simply a matter of time before someone figures it out, thinking otherwise is simply naive. Avast and ClamXav cost me nothing monetarily, nor time in productivity. This is a safety net that costs little more than a few minutes of your time period.
There are many compelling reasons to run Avast, ClamXav or similar, and few if any not too. Personal choices aside I fundamentally believe that suggesting that OS X is 100% safe to all and does not need such tools is very much a step in the wrong direction; not all are technically minded, neither do all users who may have access to systems follow safe computing rules and guidelines. The vast majority simply point and click to get to where or what they want, Avast or ClamXav simply serves as a barrier to protect those that are unaware, and some cases unconcerned, ultimately such safeguards protect the community as a whole.
Install, don’t install it`s down to you...