Mostly cost, maybe performance (depending on your network connection). For example, AWS is surprisingly expensive if you want to get a Windows EC2 instance with a GPU, or use Amazon Workspace.
An 8 vCPU (i.e. 4 full cores) / 15GB / with 4GB GPU Windows Workspace costs $22/month PLUS $1.75 per hour, or a whopping $735 per month 24x7 (
https://aws.amazon.com/workspaces/pricing/)
ShadowTech is a lot cheaper, but I don't know whether this has the same service levels as AWS.
A more portable solution that actually exists are micro PCs like the Intel NUC. Just run them headless and remote-desktop into them. I have one attached to my telescope to allow me to control it remotely.