I'm there and it's nowhere near as comfortable for me, and I have a taller friend who has one of these larger Samsung phones and he can't. On the flip side I know some people who probably could (they've definitely got big hands). Heck, comfortable operation starts to end for average hands just past the iPhone.
If your hands are somewhat average I'd suggest you try it out and notice the difference in your hand movement but I don't really expect people to be too open to this sort of thing. Some people just like large screens and that's okay.
I owned the iP4, as did my wife. I bought the S2 and it immediately felt better. The iP4 is almost to small. When I would go back and forth between phones, I hnestly don't know how I used the iPhone for the last 4 years!