The trick is surpass SATA bottleneck
When saying 500GB Samsung SSD... you mean a standard 2.5" SATA ? Then you'll be getting over 500Mb read/write, if using a USB 3.1 gen2... which uses usb-C connector.
Real Thunderbolt external cases are quite expensive, because they can use the much higher speed of PCIe (Thunderbolt special spec).
There's a lot of confusion about Thunderbolt , usb 3, usb 3.1 (gen1, gen2) and usb-C (that refers just to connector).
The SSD part of Fusion Disk will be faster, as said, for start up. Changing internal HD & installing a SSD is a good solution (if you can make it).
Having an external SATA drive for content & media is an easy solution. Everybody likes Samsung T5 (usb 3.1 gen2, thunderbolt compatible), but you can achieve similar speeds with cheaper SSDs.