For my workaround people using BT keyboard and mouse lose ability to wakeup their computer with these devices when BT is off.Filed bug (FB9864403). This appears to be a regression in macOS. Very similar DarkWake issue after the 10.13.4 update (which Apple finally fixed in 10.14).
In my case, iMac Pro with Apple's BT keyboard and magic mouse. Three LaCie RAIDs connected to a single Thunderbolt 3 port. The iMac will sleep its display, the RAIDs begin to sleep, but then immediately wake, then sleep, wake, etc. indefinitely.
Workaround is to do a complete system shutdown overnight rather than sleeping. Thankfully the iMac Pro cold boot is very fast (about 30 to 40 seconds).
It might be needed to keep keyboard connected with USB cable.