Then don't set it under stress. With normal applications (CUDA/OpenCL/gaming) GTX 980/GTX Titan X reaches max. 233 Watt:
http://www.tomshardware.com/reviews/nvidia-geforce-gtx-980-ti,4164-7.html
No, even 150W is unsafe, cause the GPU could draw them all from the 8 pin, which is connected to a mini6 pin, which -per specs- should only deliver 75W.
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I personally won't consider Pixlas is a "safe" recommendation. We don't even know what the actual limit is. It's way outside Apple's official recommendation. Officially, any hardware mod are unsafe. But we know is that just work.
Not a big difference then pulling 100W from the mini 6pin. It's hard to call it safe. But we know it works.
If by "officially" you mean "according to Apple PR", then sure - Apple will tell you it's not safe. Hell, no user-servicing is safe, not even installing a SATA SSD into our cMPs by yourself, according to Apple.
Truth is that this mod has for obvious reasons never been officially
approved (if they even know about its existence ) but it is technically electrically safe.
Point being that electronics don't need to be officially approved, for them to work and be safe.
On top of that, installing this mod, or drawing having extra power from SATA ports or using an external PSU
are unequivocally safer methods than pulling more than 75W on a connection which per spec should deliver max 75W.
Personally, we have had many customers who experienced shutdowns, because they installed GPUs the way Create Pro and MacVidCards told them (At a point that Create Pro changed their policy, and are now providing a special cable for that 8 pin, which draws power directly drom the two CD bay sata ports)
These shutdowns were not a problem anymore after the Pixlas PSU mod (which, for those who don't know it, just splits power from the Mac Pro's PSU 12V rails and its grounds to two additional 8 Pin cables).