Probably not. You are probably not boing be able to pull power from the MPX bay 1 and put it into a card in MPX bay 2. Even if can also probably not going to get usage of the MPX bay 2 8-pin power feed not to conflict with the second PCI-e slot in Bay 2.
Illustrative is right on Belkin power cable page.
https://www.apple.com/shop/product/HMUJ2ZM/A/belkin-aux-power-cable-kit-for-mac-pro
See how the cables come out and around to the card above. That soaks up space. I know folks have been hand waving about how you'll be able to snake cords thru multiple 90 changes of directions with zero cable bend, but that is probably not true.
That second x16 slot in BAY is good for perhaps a PCI-e SSD card, but a full length , max double wide, relatively high card is probably going to have major problems finding a source to plug into.
Two Radeon VIIs and 'eject' the 580X ? yes that will work. ( but back to not driving the XDR or thunderbolt ..... without some giant, Rube Goldberg kludges ).
No. The 580X can run the XDR just fine off of the default system TBv3 ports. MBP 16" can run XDR. About everything released in 2019 can run the XDR. (the iMac Pro can run it in 5K mode. Not particularly cost effective but illustrative of extent of "minimal" requirements here. )
It will run nicer with an Vega II, but it isn't a minimal requirement.
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Do those project correlate with certain attributes of the projects. For example 8K video transcoding spikes higher usage. If that is a long term growth trend for you workload demographics then will be a bigger deal over time.
Similar issue with size of resolution screen dealing with. ( size and scope/complexity of what is in active view).
There are some apps though than can barely make use of a single GPU (or its VRAM). If that's the primary tool then yeah there isn't much "bang for the buck" in Vega II. But the apps that following closely on the leading edge of Metal there is a substantive difference. Even more so if can shift data over to the VRAM size. ( two Vega II coupled together is 64GB of space. ]