You could try steam mover, and then redirect steam (not sure about the results, haven't tried that). I don't know if the problem is the skyrim location, or the location of steam, or both.
So, also on a MBP 2016 15" w/ Touchbar:
After fiddling with this some more, here's what I get: in a vanilla install, most of my sounds work, except for weapons sheathing and PC noises (weirdly enough magic sounds work fine, no clue about thums). I can actually hear occasional sheathing/PC sounds, but they seem to be coming in with a massive lag, and/or only at certain camera angles. So I wonder if it's actually several different problems, with both permissions and driver. Has anyone tested the game with a different sound driver (say, a bluetooth headset?)
For what it's worth, using a modded version of the game that replaces all vanilla sounds with a mod doesn't solve the problem.
I mostly play using a Bluetooth headset and the problem is the same: no in-game music and limited sounds.